Russia’s Ministry of Science and Higher Education on Thursday announced that researchers had developed an innovative drug delivery system based on a thermo-sensitive gel for cancer treatment.
The ministry said the G. A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences (ICS RAS) developed the gel.
According to the researchers, the gel will deliver the drug directly to the tumour, increasing treatment effectiveness and reducing the body's toxic burden.
Natalya Kochkina, PhD in Technical Sciences and Senior Research Fellow at the “Chemistry of oligosaccharides and functional materials on their basis”, explained that “Thermosensitive gels are one of the most promising areas in modern pharmaceuticals.
“The essence of our development is to create an aqueous solution containing a polymer and a drug substance, which, when administered into the body, rapidly transforms into a gel under the influence of body temperature.
“This dosage form does not spread, remains securely in the affected area, and ensures targeted action on the tumour.’’
The researchers chose 5-fluorouracil as the active ingredient. This drug is recognised as the “gold standard” in cancer treatment.
Hydroxypropyl methylcellulose, a biocompatible polymer, formed the basis of the new gels. It is used in medicine due to its safety, good solubility, and ability to stabilise formulations.
However, in its pure form, the polymer does not solidify at human body temperature; it requires over 50 degrees Celsius to do so.
It turned out that 5-fluorouracil itself lowers the solution’s setting temperature.
To fine-tune this parameter, the scientists added physiological salts.
This made it possible to achieve solidification at 36–37 degrees Celsius, that is, at body temperature.
This paves the way for localised chemotherapy: the drug can act precisely where it is needed.
Discussion0